diff --git a/target/s390x/helper.h b/target/s390x/helper.h
index a1b169b666..fb50b404db 100644
--- a/target/s390x/helper.h
+++ b/target/s390x/helper.h
@@ -224,6 +224,12 @@ DEF_HELPER_FLAGS_4(gvec_vfee32, TCG_CALL_NO_RWG, void, ptr, cptr, cptr, i32)
 DEF_HELPER_5(gvec_vfee_cc8, void, ptr, cptr, cptr, env, i32)
 DEF_HELPER_5(gvec_vfee_cc16, void, ptr, cptr, cptr, env, i32)
 DEF_HELPER_5(gvec_vfee_cc32, void, ptr, cptr, cptr, env, i32)
+DEF_HELPER_FLAGS_4(gvec_vfene8, TCG_CALL_NO_RWG, void, ptr, cptr, cptr, i32)
+DEF_HELPER_FLAGS_4(gvec_vfene16, TCG_CALL_NO_RWG, void, ptr, cptr, cptr, i32)
+DEF_HELPER_FLAGS_4(gvec_vfene32, TCG_CALL_NO_RWG, void, ptr, cptr, cptr, i32)
+DEF_HELPER_5(gvec_vfene_cc8, void, ptr, cptr, cptr, env, i32)
+DEF_HELPER_5(gvec_vfene_cc16, void, ptr, cptr, cptr, env, i32)
+DEF_HELPER_5(gvec_vfene_cc32, void, ptr, cptr, cptr, env, i32)
 
 #ifndef CONFIG_USER_ONLY
 DEF_HELPER_3(servc, i32, env, i64, i64)
diff --git a/target/s390x/insn-data.def b/target/s390x/insn-data.def
index d8907ef6a5..d03c1ee0b3 100644
--- a/target/s390x/insn-data.def
+++ b/target/s390x/insn-data.def
@@ -1197,6 +1197,8 @@
     F(0xe782, VFAE,    VRR_b, V,   0, 0, 0, 0, vfae, 0, IF_VEC)
 /* VECTOR FIND ELEMENT EQUAL */
     F(0xe780, VFEE,    VRR_b, V,   0, 0, 0, 0, vfee, 0, IF_VEC)
+/* VECTOR FIND ELEMENT NOT EQUAL */
+    F(0xe781, VFENE,   VRR_b, V,   0, 0, 0, 0, vfene, 0, IF_VEC)
 
 #ifndef CONFIG_USER_ONLY
 /* COMPARE AND SWAP AND PURGE */
diff --git a/target/s390x/translate_vx.inc.c b/target/s390x/translate_vx.inc.c
index 848f6d7163..e36cc5c401 100644
--- a/target/s390x/translate_vx.inc.c
+++ b/target/s390x/translate_vx.inc.c
@@ -2415,3 +2415,34 @@ static DisasJumpType op_vfee(DisasContext *s, DisasOps *o)
     }
     return DISAS_NEXT;
 }
+
+static DisasJumpType op_vfene(DisasContext *s, DisasOps *o)
+{
+    const uint8_t es = get_field(s->fields, m4);
+    const uint8_t m5 = get_field(s->fields, m5);
+    static gen_helper_gvec_3_ptr * const cc[3] = {
+        gen_helper_gvec_vfene_cc8,
+        gen_helper_gvec_vfene_cc16,
+        gen_helper_gvec_vfene_cc32,
+    };
+    static gen_helper_gvec_3 * const nocc[3] = {
+        gen_helper_gvec_vfene8,
+        gen_helper_gvec_vfene16,
+        gen_helper_gvec_vfene32,
+    };
+
+    if (es > ES_32 || m5 & ~0x3) {
+        gen_program_exception(s, PGM_SPECIFICATION);
+        return DISAS_NORETURN;
+    }
+
+    if (m5 & 1) {
+        gen_gvec_3_ptr(get_field(s->fields, v1), get_field(s->fields, v2),
+                       get_field(s->fields, v3), cpu_env, m5, cc[es]);
+        set_cc_static(s);
+    } else {
+        gen_gvec_3_ool(get_field(s->fields, v1), get_field(s->fields, v2),
+                       get_field(s->fields, v3), m5, nocc[es]);
+    }
+    return DISAS_NEXT;
+}
diff --git a/target/s390x/vec_string_helper.c b/target/s390x/vec_string_helper.c
index 6a5d05271c..181f044fe5 100644
--- a/target/s390x/vec_string_helper.c
+++ b/target/s390x/vec_string_helper.c
@@ -154,3 +154,56 @@ void HELPER(gvec_vfee_cc##BITS)(void *v1, const void *v2, const void *v3,      \
 DEF_VFEE_CC_HELPER(8)
 DEF_VFEE_CC_HELPER(16)
 DEF_VFEE_CC_HELPER(32)
+
+#define DEF_VFENE(BITS)                                                        \
+static int vfene##BITS(void *v1, const void *v2, const void *v3, uint8_t m5)   \
+{                                                                              \
+    const bool zs = extract32(m5, 1, 1);                                       \
+    S390Vector tmp = {};                                                       \
+    int first_byte = 16;                                                       \
+    int cc = 3; /* no match */                                                 \
+    int i;                                                                     \
+                                                                               \
+    for (i = 0; i < (128 / BITS); i++) {                                       \
+        const uint##BITS##_t data1 = s390_vec_read_element##BITS(v2, i);       \
+        const uint##BITS##_t data2 = s390_vec_read_element##BITS(v3, i);       \
+                                                                               \
+        if (data1 != data2) {                                                  \
+            first_byte = i * (BITS / 8);                                       \
+            cc = data1 < data2 ? 1 : 2; /* inequality found */                 \
+            break;                                                             \
+        }                                                                      \
+                                                                               \
+        if (zs && !data1) {                                                    \
+            first_byte = i * (BITS / 8);                                       \
+            cc = 0; /* match for zero */                                       \
+            break;                                                             \
+        }                                                                      \
+    }                                                                          \
+    s390_vec_write_element8(&tmp, 7, first_byte);                              \
+    *(S390Vector *)v1 = tmp;                                                   \
+    return cc;                                                                 \
+}
+DEF_VFENE(8)
+DEF_VFENE(16)
+DEF_VFENE(32)
+
+#define DEF_VFENE_HELPER(BITS)                                                 \
+void HELPER(gvec_vfene##BITS)(void *v1, const void *v2, const void *v3,        \
+                              uint32_t desc)                                   \
+{                                                                              \
+    vfene##BITS(v1, v2, v3, simd_data(desc));                                  \
+}
+DEF_VFENE_HELPER(8)
+DEF_VFENE_HELPER(16)
+DEF_VFENE_HELPER(32)
+
+#define DEF_VFENE_CC_HELPER(BITS)                                              \
+void HELPER(gvec_vfene_cc##BITS)(void *v1, const void *v2, const void *v3,     \
+                                CPUS390XState *env, uint32_t desc)             \
+{                                                                              \
+    env->cc_op = vfene##BITS(v1, v2, v3, simd_data(desc));                     \
+}
+DEF_VFENE_CC_HELPER(8)
+DEF_VFENE_CC_HELPER(16)
+DEF_VFENE_CC_HELPER(32)
