diff --git a/DEVELOPERS b/DEVELOPERS
index 399b2931ff3..b8beb1bd565 100644
--- a/DEVELOPERS
+++ b/DEVELOPERS
@@ -1872,6 +1872,7 @@ F:	support/testing/tests/package/test_usbutils.py
 F:	support/testing/tests/package/test_usbutils/
 F:	support/testing/tests/package/test_weston.py
 F:	support/testing/tests/package/test_weston/
+F:	support/testing/tests/package/test_wine.py
 F:	support/testing/tests/package/test_xz.py
 F:	support/testing/tests/package/test_z3.py
 F:	support/testing/tests/package/test_z3/
diff --git a/support/testing/tests/package/test_wine.py b/support/testing/tests/package/test_wine.py
new file mode 100644
index 00000000000..4e5b4a8b111
--- /dev/null
+++ b/support/testing/tests/package/test_wine.py
@@ -0,0 +1,88 @@
+import os
+
+import infra.basetest
+
+
+class TestWine(infra.basetest.BRTest):
+    # Wine depends on i386 architecture. The pre-build runtime test
+    # Kernel (for armv5) cannot be used. The config also uses a ext4
+    # rootfs due to the larger Wine footprint. We also enable NLS,
+    # which is required for cmd.exe shell to work.
+    config = \
+        """
+        BR2_i386=y
+        BR2_x86_pentium4=y
+        BR2_TOOLCHAIN_EXTERNAL=y
+        BR2_LINUX_KERNEL=y
+        BR2_LINUX_KERNEL_CUSTOM_VERSION=y
+        BR2_LINUX_KERNEL_CUSTOM_VERSION_VALUE="6.6.27"
+        BR2_LINUX_KERNEL_USE_CUSTOM_CONFIG=y
+        BR2_LINUX_KERNEL_CUSTOM_CONFIG_FILE="board/qemu/x86/linux.config"
+        BR2_LINUX_KERNEL_NEEDS_HOST_OPENSSL=y
+        BR2_LINUX_KERNEL_NEEDS_HOST_LIBELF=y
+        BR2_PACKAGE_WINE=y
+        BR2_SYSTEM_ENABLE_NLS=y
+        BR2_TARGET_ROOTFS_EXT2=y
+        BR2_TARGET_ROOTFS_EXT2_4=y
+        BR2_TARGET_ROOTFS_EXT2_SIZE="256M"
+        # BR2_TARGET_ROOTFS_TAR is not set
+        """
+
+    def test_run(self):
+        drive = os.path.join(self.builddir, "images", "rootfs.ext4")
+        kern = os.path.join(self.builddir, "images", "bzImage")
+        self.emulator.boot(arch="i386",
+                           kernel=kern,
+                           kernel_cmdline=["root=/dev/vda console=ttyS0"],
+                           options=["-M", "pc", "-m", "256M",
+                                    "-drive", f"file={drive},if=virtio,format=raw"])
+        self.emulator.login()
+
+        # Check the program can run.
+        self.assertRunOk("wine --version")
+
+        # Remove the Wine directory to make this test idempotent. This
+        # is because we use a persistent storage. This is useful only
+        # when the run-tests script is used with the "-k" option.
+        self.assertRunOk("rm -rf ~/.wine")
+
+        # Wine usually prints lots of debug messages. We disable all
+        # logs for this test. For debugging, this line can be
+        # commented, or extra log can also be added. "WINEDEBUG=+all"
+        # enable all logs and generates a lot of messages.
+        # See: https://wiki.winehq.org/Debug_Channels
+        self.assertRunOk("export WINEDEBUG=-all")
+
+        # We force the initialization of the WINEPREFIX
+        # directory. This operation can take some time. This will make
+        # subsequent wine invocation execution time more stable.
+        self.assertRunOk("wineboot --init", timeout=45)
+
+        # We check we can list files in the Windows OS directory.
+        cmd = "wine cmd.exe /C 'DIR C:\\WINDOWS\\'"
+        self.assertRunOk(cmd, timeout=10)
+
+        # We check we can read a Windows OS specific environment
+        # variable. We use "assertIn" rather than "assertEqual"
+        # because the cmd.exe shell write extra control characters.
+        cmd = "wine cmd.exe /C 'ECHO %OS%'"
+        out, ret = self.emulator.run(cmd, timeout=10)
+        self.assertEqual(ret, 0)
+        self.assertIn("Windows_NT", out[0])
+
+        # We check we can print an arbitrary string with the
+        # cmd.exe shell.
+        string = "Hello Buildroot !"
+        cmd = f"wine cmd.exe /C 'ECHO {string}'"
+        out, ret = self.emulator.run(cmd, timeout=10)
+        self.assertEqual(ret, 0)
+        self.assertIn(string, out[0])
+
+        # We check the VER command reports a Windows OS version.
+        cmd = "wine cmd.exe /C 'VER'"
+        out, ret = self.emulator.run(cmd, timeout=10)
+        self.assertEqual(ret, 0)
+        self.assertIn("Microsoft Windows", "\n".join(out))
+
+        # We run the ping.exe command.
+        self.assertRunOk("wine ping.exe 127.0.0.1", timeout=10)
