diff --git a/qapi/block-core.json b/qapi/block-core.json
index 2c107823fe..5c5921bfb7 100644
--- a/qapi/block-core.json
+++ b/qapi/block-core.json
@@ -2521,6 +2521,11 @@
 # @l2-cache-size:         the maximum size of the L2 table cache in
 #                         bytes (since 2.2)
 #
+# @l2-cache-entry-size:   the size of each entry in the L2 cache in
+#                         bytes. It must be a power of two between 512
+#                         and the cluster size. The default value is
+#                         the cluster size (since 2.12)
+#
 # @refcount-cache-size:   the maximum size of the refcount block cache
 #                         in bytes (since 2.2)
 #
@@ -2542,6 +2547,7 @@
             '*overlap-check': 'Qcow2OverlapChecks',
             '*cache-size': 'int',
             '*l2-cache-size': 'int',
+            '*l2-cache-entry-size': 'int',
             '*refcount-cache-size': 'int',
             '*cache-clean-interval': 'int',
             '*encrypt': 'BlockdevQcow2Encryption' } }
diff --git a/block/qcow2.h b/block/qcow2.h
index d956a6cdd2..883802241f 100644
--- a/block/qcow2.h
+++ b/block/qcow2.h
@@ -68,7 +68,7 @@
 #define MAX_CLUSTER_BITS 21
 
 /* Must be at least 2 to cover COW */
-#define MIN_L2_CACHE_SIZE 2 /* clusters */
+#define MIN_L2_CACHE_SIZE 2 /* cache entries */
 
 /* Must be at least 4 to cover all cases of refcount table growth */
 #define MIN_REFCOUNT_CACHE_SIZE 4 /* clusters */
@@ -100,6 +100,7 @@
 #define QCOW2_OPT_OVERLAP_INACTIVE_L2 "overlap-check.inactive-l2"
 #define QCOW2_OPT_CACHE_SIZE "cache-size"
 #define QCOW2_OPT_L2_CACHE_SIZE "l2-cache-size"
+#define QCOW2_OPT_L2_CACHE_ENTRY_SIZE "l2-cache-entry-size"
 #define QCOW2_OPT_REFCOUNT_CACHE_SIZE "refcount-cache-size"
 #define QCOW2_OPT_CACHE_CLEAN_INTERVAL "cache-clean-interval"
 
@@ -647,7 +648,8 @@ void qcow2_free_snapshots(BlockDriverState *bs);
 int qcow2_read_snapshots(BlockDriverState *bs);
 
 /* qcow2-cache.c functions */
-Qcow2Cache *qcow2_cache_create(BlockDriverState *bs, int num_tables);
+Qcow2Cache *qcow2_cache_create(BlockDriverState *bs, int num_tables,
+                               unsigned table_size);
 int qcow2_cache_destroy(Qcow2Cache *c);
 
 void qcow2_cache_entry_mark_dirty(Qcow2Cache *c, void *table);
diff --git a/block/qcow2-cache.c b/block/qcow2-cache.c
index b1aa42477e..d9dafa31e5 100644
--- a/block/qcow2-cache.c
+++ b/block/qcow2-cache.c
@@ -120,14 +120,20 @@ void qcow2_cache_clean_unused(Qcow2Cache *c)
     c->cache_clean_lru_counter = c->lru_counter;
 }
 
-Qcow2Cache *qcow2_cache_create(BlockDriverState *bs, int num_tables)
+Qcow2Cache *qcow2_cache_create(BlockDriverState *bs, int num_tables,
+                               unsigned table_size)
 {
     BDRVQcow2State *s = bs->opaque;
     Qcow2Cache *c;
 
+    assert(num_tables > 0);
+    assert(is_power_of_2(table_size));
+    assert(table_size >= (1 << MIN_CLUSTER_BITS));
+    assert(table_size <= s->cluster_size);
+
     c = g_new0(Qcow2Cache, 1);
     c->size = num_tables;
-    c->table_size = s->cluster_size;
+    c->table_size = table_size;
     c->entries = g_try_new0(Qcow2CachedTable, num_tables);
     c->table_array = qemu_try_blockalign(bs->file->bs,
                                          (size_t) num_tables * c->table_size);
diff --git a/block/qcow2.c b/block/qcow2.c
index 953254a004..57a517e2bd 100644
--- a/block/qcow2.c
+++ b/block/qcow2.c
@@ -676,6 +676,11 @@ static QemuOptsList qcow2_runtime_opts = {
             .help = "Maximum L2 table cache size",
         },
         {
+            .name = QCOW2_OPT_L2_CACHE_ENTRY_SIZE,
+            .type = QEMU_OPT_SIZE,
+            .help = "Size of each entry in the L2 cache",
+        },
+        {
             .name = QCOW2_OPT_REFCOUNT_CACHE_SIZE,
             .type = QEMU_OPT_SIZE,
             .help = "Maximum refcount block cache size",
@@ -747,6 +752,7 @@ static void qcow2_attach_aio_context(BlockDriverState *bs,
 
 static void read_cache_sizes(BlockDriverState *bs, QemuOpts *opts,
                              uint64_t *l2_cache_size,
+                             uint64_t *l2_cache_entry_size,
                              uint64_t *refcount_cache_size, Error **errp)
 {
     BDRVQcow2State *s = bs->opaque;
@@ -762,6 +768,9 @@ static void read_cache_sizes(BlockDriverState *bs, QemuOpts *opts,
     *refcount_cache_size = qemu_opt_get_size(opts,
                                              QCOW2_OPT_REFCOUNT_CACHE_SIZE, 0);
 
+    *l2_cache_entry_size = qemu_opt_get_size(
+        opts, QCOW2_OPT_L2_CACHE_ENTRY_SIZE, s->cluster_size);
+
     if (combined_cache_size_set) {
         if (l2_cache_size_set && refcount_cache_size_set) {
             error_setg(errp, QCOW2_OPT_CACHE_SIZE ", " QCOW2_OPT_L2_CACHE_SIZE
@@ -802,6 +811,15 @@ static void read_cache_sizes(BlockDriverState *bs, QemuOpts *opts,
                                  / DEFAULT_L2_REFCOUNT_SIZE_RATIO;
         }
     }
+
+    if (*l2_cache_entry_size < (1 << MIN_CLUSTER_BITS) ||
+        *l2_cache_entry_size > s->cluster_size ||
+        !is_power_of_2(*l2_cache_entry_size)) {
+        error_setg(errp, "L2 cache entry size must be a power of two "
+                   "between %d and the cluster size (%d)",
+                   1 << MIN_CLUSTER_BITS, s->cluster_size);
+        return;
+    }
 }
 
 typedef struct Qcow2ReopenState {
@@ -824,7 +842,7 @@ static int qcow2_update_options_prepare(BlockDriverState *bs,
     QemuOpts *opts = NULL;
     const char *opt_overlap_check, *opt_overlap_check_template;
     int overlap_check_template = 0;
-    uint64_t l2_cache_size, refcount_cache_size;
+    uint64_t l2_cache_size, l2_cache_entry_size, refcount_cache_size;
     int i;
     const char *encryptfmt;
     QDict *encryptopts = NULL;
@@ -843,15 +861,15 @@ static int qcow2_update_options_prepare(BlockDriverState *bs,
     }
 
     /* get L2 table/refcount block cache size from command line options */
-    read_cache_sizes(bs, opts, &l2_cache_size, &refcount_cache_size,
-                     &local_err);
+    read_cache_sizes(bs, opts, &l2_cache_size, &l2_cache_entry_size,
+                     &refcount_cache_size, &local_err);
     if (local_err) {
         error_propagate(errp, local_err);
         ret = -EINVAL;
         goto fail;
     }
 
-    l2_cache_size /= s->cluster_size;
+    l2_cache_size /= l2_cache_entry_size;
     if (l2_cache_size < MIN_L2_CACHE_SIZE) {
         l2_cache_size = MIN_L2_CACHE_SIZE;
     }
@@ -889,9 +907,11 @@ static int qcow2_update_options_prepare(BlockDriverState *bs,
         }
     }
 
-    r->l2_slice_size = s->cluster_size / sizeof(uint64_t);
-    r->l2_table_cache = qcow2_cache_create(bs, l2_cache_size);
-    r->refcount_block_cache = qcow2_cache_create(bs, refcount_cache_size);
+    r->l2_slice_size = l2_cache_entry_size / sizeof(uint64_t);
+    r->l2_table_cache = qcow2_cache_create(bs, l2_cache_size,
+                                           l2_cache_entry_size);
+    r->refcount_block_cache = qcow2_cache_create(bs, refcount_cache_size,
+                                                 s->cluster_size);
     if (r->l2_table_cache == NULL || r->refcount_block_cache == NULL) {
         error_setg(errp, "Could not allocate metadata caches");
         ret = -ENOMEM;
